Abnormal bruising, Abnormal skin pigmentation, Anemia, Change in blood test results, Dizziness, Headache, Vomiting, Weakness, Diarrhoea, Nausea.
Pyrimethamine is a weak base that reaches high concentration within the malarial parasite and causes accumulation of toxic heme pigment, which kills it.
- Do not start or continue the artesunate tablets and consult your doctor If you are allergic (hypersensitive) to artesunate.
- Do not start or continue the artesunate tablets and consult your doctor you are in first 3 months of pregnancy or If you are breast feeding.
- Do not drive or operate machinery after taking artesunate because you may feel sleepy.
- Take sulfadoxine along with food to minimize gastrointestinal side effects.
- Take sulfadoxine with plenty of water to prevent crystalluria (crystals found in the urine when performing a urine test).
- Avoid excessive sun exposure and wear protective clothing while taking sulfadoxine, as it may increase sensitivity to sunlight.
- Seek immediate medical attention if you experience signs of rash or any other allergic reaction or folate deficiency (low level of folic acid in the body).
- You will be regularly monitored for complete blood count, liver function tests, analysis of urine for crystalluria if sulfadoxine is administered for > 3 months.
- Do not drive or operate any machinery while taking sulfadoxine as it may cause dizziness.
- Do not take if patient is allergic to sulfadoxine or any of its ingredients.
- Do not take if patients with impaired kidney or liver function, blood dyscrasias (a diseased state of blood), folate deficiency, severe allergy or bronchial asthma, G6PD deficiency.
- Do not given to Children less than 2 months.
- Do not given to regnant women at term and breastfeeding women.
- Pyrimethamine when given with sulphonamide, it should be given with folic acid (vitamin) supplement.
- Do not use pyrimethamine if you are allergic to pyrimethamine or any other ingredient.
- Do not take pyrimethamine if you have megaloblastic anemia due to folate deficiency.
- Do not take pyrimethamine if you have kidney or liver problems; fits (seizures); depression; bone marrow problems; stomach or bowel problems (eg, malabsorption syndrome); phenylketonuria, or alcoholism.
warnings
Alcohol
Pregnancy
Lactation
Driving
Kidney
Liver
