Lupome D Capsule is a combination of two medicines: Domperidone and Omeprazole which relieve symptoms of gastroesophageal reflux disease (GERD). Domperidone is a prokinetic which works on the region in the brain that controls vomiting. It also acts on the upper digestive tract and helps food move more easily through the stomach. Omeprazole is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps relieve acid-related indigestion and heartburn.